A crafty teaser that presents itself as one kind of film before gradually evolving into another kind altogether. I, for one, enjoyed both enormously. Christopher Orr-The Atlantic
Steven Soderbergh is one of our best and most versatile directors. Richard Roeper-Richard Roeper.com
Side Effects is a cracking thriller that ranks amongst Soderbergh's best, featuring electric performances by Rooney Mara, Jude Law, Catherine Zeta-Jones and Channing Tatum. Peter Howell-Toronto Star
Side Effects virtually demands a three-word review: Just see it. Richard Corliss-TIME Magazine
The main thing to keep in mind while watching Steven Soderbergh's playful new thriller is not to take the movie too seriously or else you'll feel betrayed by the end. Rene Rodriguez-Miami Herald
Soderbergh and screenwriter Scott Z. Burns maintain a tone of taut creepiness, but the plot's double and triple crosses are more ingenious than believable. Peter Rainer-Christian Science Monitor
I'm not a big fan of psychological dramas, but this is an exceptionally good one. It keeps you guessing right up to the end. I'm not a big fan of Jude Law, either, but he does a good job in this film. Robert Roten-Laramie Movie Scope
Sleek and stylish yet silly and far-fetched, it dissolves into a cinematic depressant. Susan Granger-SSG Syndicate
Soderbergh is so adept at drawing us into his cinematic web we are not aware that we've been cocooned for later consumption Andrew L. Urban-Urban Cinefile
At times a trifle too clever for its own good, there are moments that push the bounds of credibility, yet the four leads keep us riveted, their characters becoming entwined inextricably as the exposition changes direction all the while Louise Keller-Urban Cinefile
Soderbergh's latest (and possibly last) proves involving right until the penultimate act Robert Denerstein-Movie Habit
surprisingly complex medical thriller Mark R. Leeper-Mark Leeper's Reviews
A multi-layered and expertly-woven thriller. Jamie Neish-HeyUGuys
Side Effects boasts a fine cast, an authentic milieu and a script that flirts with the experimental. But it also underwhelms in the crucial final third. James Mottram-The List
As smart and stylish as one would expect, but like Soderbergh's other recent artsy genre essays - 'Haywire,' 'Contagion' - its duller than its sources (in this case, 'Bigger Than Life,' 'Basic Instinct' and 'Psycho'). John Beifuss-Commercial Appeal (Memphis, TN)
a slick, entertaining piece of Hollywood genre work that includes just enough twists and tweaks to make it stand out from the parade of similar thrillers James Kendrick-Q Network Film Desk
Starting off in one place and ending somewhere else entirely, Soderbergh's sleek mystery takes pot-shots at Big Pharma while still delivering a polished genre product that's rarely hard to swallow. Neil Smith-Total Film
Bold and aggressive and completely sure of itself. Tim Brayton-Antagony & Ecstasy
When all's said and done, it'll go down as minor Soderbergh - clever sleight-of-hand, really - but it reminds you of so many Soderberghy virtues as to be an oddly compendious pleasure. Tim Robey-Daily Telegraph
I'm curious to see how the film holds up and changes on a second viewing because there is a lot at work here. Greg Maki-Star-Democrat (Easton, MD)
Side Effects sports two very strong performances from Law and Mara, and Soderbergh's direction is lean and efficient. If only the final act were as muscular and sure-footed as the rest of the movie. Eric Melin-Lawrence.com
The acting is good and the plot is intense; if you work hard you will find some entertainment. Jackie K. Cooper-jackiekcooper.com
No spoilers: Side Effects is damn good at being a movie. Vincent Mancini-FilmDrunk
As surprises and weirdnesses and lurid plot points create a landscape of miniature explosions, Soderbergh retains control over the simultaneously bleak, moody, goofy, serious and un-serious momentum. Dave White-Movies.com
Hitch used illogic, but he never plummeted into hokum as Side Effects does. Tony Macklin-tonymacklin.net
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